What began as a local alert revealed a global problem in more than 30 countries and involving more than thirty brands. [74], In the first week of 2020, around 17 children from Ramnagar, in the union territory of Jammu and Kashmir, were hospitalised, more than half of whom died of kidney failure. available from the NIST/EPA/NIH Mass Spectral Library. Only 88 children deaths were recalled by doctors or had medical records. Soon thereafter, patients died after receiving the medication. Used as a solvator for PVC, plasticizer in elastomers, in vinyl flooring, adhesives, latex caulks and sealants, color concentrates for PVC, and castable polyurethanes; [EPA ChAMP . Only approximately 3,000 bottles had been analyzed from the total 6,000 bottles collected. During September 1986, the Ministry of Public Works started testing a mixture of wine with salt to melt hazardous ice during winter. It was assumed that DEG was used as a substitute of propylene glycol, and this incident encouraged the Nigerian government to develop pharmaceutical quality control guidelines. 27138-31-4 . Dietary administration of EDC mixtures: A focus on fish lipid metabolism. Epub 2016 Nov 14. The children later developed kidney failure and died. Gihi Chemicals Co., Limited is supplier for Diethylene glycol dibenzoate. [2][23], Patients being treated for burns developed sudden anuric kidney failure. [20][21][22] This episode was the impetus for the Federal Food, Drug, and Cosmetic Act of 1938. Reuter. It has good oxidization & volatilization, extraction and low release. [4], The physical properties of diethylene glycol make it an excellent counterfeit for pharmaceutical-grade glycerine (also called glycerol) or propylene glycol, and has caused many deaths in different countries. Both ethylene glycol and diethylene glycol are produced from same starting material; ethylene. Standard Reference Data Act. Bethesda, MD 20894, Web Policies Rat models suggest DEG is metabolized in the liver by enzyme NAD-dependent alcohol dehydrogenase (ADH) into a hydrogen ion, NADH and 2-hydroxyethoxyacetaldehyde (C4H8O3). Diethylene Glycol Dibenzoate is used in analytical studies to investigation into the migration potential of coating materials from cookware products. Investigations revealed that all had taken a medicine called My Pikin Baby, a teething mixture tainted with diethylene glycol. [9] The Government of Australia does not allow DEG as a food additive due its toxicity; it is only allowed at less than 0.25% w/w of DEG as an impurity of polyethylene glycol (PEG)[10] even in toothpaste. Molecular Weight: 314.34 Molecular Formula: C18H18O5 Additional Metadata. Please login or register to add to your favourites . +49 34291 3372-39 contact@hpc-standards.com: Emergency telephone number [53][54][55] For the end of the month, the Chinese government committed to investigate the supposedly tainted toothpaste that had been recalled in Panama and Dominican Republic, but stated that, as per an essay written in 2000, a toothpaste containing 15.6% was not dangerous. The cough and cold syrups produced by Maiden Pharmaceuticals Limited, Sonepat in India. The lowest dose of BPA increased the storage of triglycerides and promoted fatty acid synthesis, while the highest concentration promoted de novo lipogenesis and cholesterologenesis. It is a blend of dipropylene glycol- and diethylene glycol dibenzoate. Differential Hepatic Gene Expression Profile of Male Fathead Minnows Exposed to Daily Varying Dose of Environmental Contaminants Individually and in Mixture. Neat. [50], Panama's case made CDC set standardized methodology for DEG identification, hoping to have more timely response in future events. An unmitigated tragedy", "Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. PubMed PMID . The Dutch authorities assessed a $250,000 fine against Vos B.V., for not alerting anyone when they tested the syrup and found impurities.[42]. Synthesis of Diethylene Glycol Dibenzoate Catalyszed by Aluminium Phosphotungstate (Unknown language) . Diethylene glycol dibenzoate. [41] As a result of the case-control findings, and subsequent investigation at the factory, public warnings were issued by the Ministry of Health and bottles of the two medications were taken from pharmacy shelves and destroyed. [11], Diethylene glycol has "moderate to low" acute toxicity[12] in animal experiments. All rights reserved. on behalf of the United States of America. It. . Ethylene glycol, diethylene glycol, maleic anhydride, dicyclopentadiene polymer 68171-28-8: Chemsrc provides Ethylene Glycol Dibenzoate . Diethylene glycol dibenzoate. Zare A, Henry D, Chua G, Gordon P, Habibi HR. GIHI CHEMICALS focus on: - Organic compounds - Active Pharmaceutical Ingredient (s) - Nutritional prod . [75][76], The WHO issued a medical product alert for four contaminated Indian pediatric medicines, manufactured by a firm in Haryanas Sonepat, saying these drugs identified in Gambia had been potentially linked with acute kidney injuries and 70 deaths among children in the west African country. Uses: Use as lubricant. of morpholine and 1,4-dioxane. MeSH [56], On June 1, 2007, the FDA warned consumers to avoid toothpaste from China, although there was no information if these toothpastes had already entered the US, and started testing any imported Chinese toothpaste. Careers. Accessibility and transmitted securely. Diethylene Glycol Dibenzoate. It is a blend of dipropylene glycol dibenzoate and diethylene glycol dibenzoate. (e.g., Japan AIST/NIMC Database- Spectrum MS-NW-5390. Among EDCs, Bisphenol A (BPA) is extensively used in the production of polycarbonate plastic, and is among the most abundant contaminants in the world. Would you like email updates of new search results? It is used as a plasticizer, antifreeze, lubricant, and liquid fuel (e.g., Sterno Wick Chafing Fuel, Des Plaines, IL). [71] On 9 January 2020, a police report indicated quantities of diethylene glycol in one brand of beer from the small upscale brewery Backer that could have poisoned 18 people in Belo Horizonte and other cities in Minas Gerais state. Patients were treated with fluid hydration and correction of acidosis, but some were not able to survive. [4] Because of its adverse effects on humans, diethylene glycol is not allowed for use in food and drugs[8] (in many countries). Papers overview. Diethylene glycol dibenzoate: Catalog No. Product Safety Tests; Energy Efficiency Tests . Data compilation copyright Acute (short-term) exposure of humans to ethylene glycol by ingesting large quantities causes three stages of health effects: central nervous system (CNS) depression, followed by a fast fusing plasticizer that allows formulators to process at lower temperatures and offer lower . At the request of the United States, the State Food and Drug Administration of China investigated Taixing Glycerine Factory and CNSC Fortune Way, but the agency concluded it is not under their jurisdiction because the factory is not certified to make medicine. It is a primary high solvating plasticizer for PVC & polyvinyl acetate adhesives. Wang Guiping discovered how easy it was to enter China's pharmaceutical supply business and earn extra money. They also arrested 12 people in connection with the incident. Molla Fenari Mahallesi Nurosmaniye Caddesi, No.75/77 K:5 D:504,Istanbul,Turkey, P.O.Box 172833, Al Mussalla Rd., Deira, Dubai, UAE, Carl-Von-Noorden-Platz 14, 60596 Frankfurt am Main, Germany. EDCs can exert adverse effects at low concentrations, often in a non-monotonic dose-related fashion. Panama awaits the extradition of Criado for her hearing. [2] In personal care products (e.g. Diethylene glycol dibenzoate 97.0%. It is a clear, colorless liquid. Diethylene glycol monobenzoate WARNING: This product is for research use only, not for human or veterinary use. jcamp-plot.js. All mass spectra in this site (plus many more) are WHO said laboratory analysis of samples of each of the four products confirmed that they contain unacceptable amounts of diethylene glycol and ethylene glycol as contaminants. Other names: Diglycol dibenzoate; Ethanol, 2,2'-oxybis-, dibenzoate; Benzo Flex 2-45; Benzoic acid, diester with diethylene glycol; Dibenzoyldiethyleneglycol ester; 2,2'-Oxydiethylene dibenzoate; 2-[2-(Benzoyloxy)ethoxy]ethyl benzoate; Ethanol, 2,2'-oxybis-, 1,1'-dibenzoate; oxydiethylene dibenzoate Permanent link for this species. The outbreak forced the government to ban the sale of paracetamol elixirs in December 1992, causing a decline of 53% in the admission of patients with kidney failure and an 84% decline in admissions by unexplained kidney failure. [2][23][32], During the summer months, 47 children were admitted to the Jos University teaching hospital, Nigeria, with anuria, fever and vomiting. Diethylene glycol dibenzoate (DGB), an approved alternative to phthalates in the production of plastic and latex products, however, is less abundant and its effects are almost completely unknown. During the month of July 1985, Austrian wines were found to contain up to 1,000 parts per million of DEG, giving them a desirable sweetness. Study on Spectrophotometric Determination of Iron by Using Polyethylene Glycol-ammonium sulfate-1,10-phenanthroline as Extracting System. Fundam Clin Pharmacol. C18 H18 O5. Plasticizers used in food-contact materials affect adipogenesis in 3T3-L1 cells. [48], The New York Times reported that Taixing was closed by the Chinese government and CNSC Fortune Way, which is also owned by the Chinese government, was never sanctioned. At the time, the food and drug laws did not require toxicological analysis before releasing for sale. Product Format. Valentina . HTML 5 canvas support. Soon, patients started to present anuria, acidic breathing, hepatomegaly, and unresponsiveness. It K-FLEX 500 by LANXESS (previously Emerald Kalama Chemical) is a non-phthalate, general-purpose, polar plasticizer. and Informatics, NIST Mass Spectrometry Data Center, William E. Wallace, director, Modified by NIST for use in this application. The aim of this study is to provide information on the hepatic effects of BPA and DGB on lipid metabolism, and investigate possible links between these contaminants and the increased incidence of obesity. Acts as a plasticizer. Diethylene Glycol (DEG) is one of the most useful products in the world that has many uses and applications in the chemical and petrochemical industry. FORMULATIONS with PROPYLENE GLYCOL DIBENZOATE. : D49-1; NC0019001; NC1483257; XXD494LI Synonyms 2,2`-Oxydiethanol; Diethylene glycol; Diglycol Recommended Use Laboratory chemicals. Related topics 2 relations . We stock inventory in warehouses throughout the United States, allowing us to serve customers in all regions in a timely and cost effective manner. View information & documentation regarding Diethylene glycol dibenzoate, including CAS, structure & more. Benzoic acid ester of dipropylene and diethylene glycol. metal, wooden and plastic construction and building Some authors suggest the minimum toxic dose is estimated at 0.14mg/kg of body weight and the lethal dose is between 1.0 and 1.63 g/kg of body weight,[7] while some suggest the LD50 in adults is of ~1 mL/kg,[2] and others suggest this is the LD30. by the U.S. Secretary of Commerce on behalf of the U.S.A. FDA Detains One Contaminated Shipment, Issues Import Alert", June 1, 2007. Fourteen patients received hemodialysis, but the treatment failed. ChemSpider ID 60118. It is used as a has an excellent compatibility with polyvinyl acetates and polyvinyl chloride. [23] This law, though extensively amended in subsequent years, remains the central foundation of FDA regulatory authority to the present day. Use as dispersing agent, emulsion stabilizer. [33] The United States Food and Drug Administration also issued an Industry Guidance Document intended to alert pharmaceutical manufacturers, pharmacy compounders, repackers, and suppliers to the potential public health hazard of glycerin contaminated with diethylene glycol (DEG) and recommended appropriate testing procedures for the use of glycerin. Massengill Co. (a Tennessee drug company), manufactured sulfanilamide dissolved with diethylene glycol, to create a liquid alternative of this drug. Before This being the second incident involving counterfeit glycerine, it prompted the Nigerian National Agency for Food And Drug Administration and Control (NAFDAC) to adopt zero tolerance for counterfeits. Epub 2020 Sep 17. The counterfeit syrup ended in ampules of Amillarisin A, a medication for gall bladder problems; special pediatric enema fluid; blood vessel disease injections; intravenous pain reliever; and an arthritis medication. Benzo Flex 2-45; Benzoic acid, diester with diethylene glycol; Dibenzoyldiethyleneglycol ester; 2,2'-Oxydiethylene dibenzoate; 2-[2-(Benzoyloxy)ethoxy]ethyl benzoate; Ethanol, 2,2'-oxybis-, 1,1'-dibenzoate; oxydiethylene dibenzoate Permanent link for this . Bogdanich, W. "Wider Sale Is Seen for Toothpaste Tainted in China ", U.S. Bureau of Alcohol, Tobacco and Firearms, Centers for Disease Control and Prevention, "Toxic alcohol ingestions: clinical features, diagnosis, and management", ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN: Polyethylene glycol, Existing Chemical Hazard Assessment Report, "Toothpaste containing more than 0.25 per cent by weight of diethylene glycol (DEG)", Australian Competition & Consumer Commission. Some were not able to survive a mixture of wine with salt to melt hazardous during. 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